PMID:11451702
| Citation |
Friedman, SM, Lu, T and Drlica, K (2001) Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region. Antimicrob. Agents Chemother. 45:2378-80 |
|---|---|
| Abstract |
In three Escherichia coli mutants, a change (Ala-51 to Val) in the gyrase A protein outside the standard quinolone resistance-determining region (QRDR) lowered the level of quinolone susceptibility more than changes at amino acids 67, 82, 84, and 106 did. Revision of the QRDR to include amino acid 51 is indicated. |
| Links |
PubMed PMC90659 Online version:10.1128/AAC.45.8.2378-2380.2001 |
| Keywords |
4-Quinolones; Anti-Infective Agents/pharmacology; DNA Gyrase; DNA Primers/chemistry; DNA Topoisomerases, Type II/genetics; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/genetics; Mutation; Polymerase Chain Reaction; Protein Conformation |
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