PMID:11403704

Citation	Begusová, M, Eon, S, Sy, D, Culard, F, Charlier, M and Spotheim-Maurizot, M (2001) Radiosensitivity of DNA in a specific protein-DNA complex: the lac repressor-lac operator complex. Int. J. Radiat. Biol. 77:645-54
Abstract	To calculate the probability of radiation-induced frank strand breakage (FSB) at each nucleotide in the Escherichia coli lac repressor-lac operator system using a simulation procedure. To compare calculated and experimental results. To asses the contribution of DNA conformational changes and of the masking by the protein to DNA protection by the repressor.
Links	PubMed Online version:10.1080/09553000110041876
Keywords	Bacterial Proteins/chemistry; Bacterial Proteins/radiation effects; Base Sequence; DNA Damage; DNA, Bacterial/chemistry; DNA, Bacterial/genetics; DNA, Bacterial/radiation effects; Escherichia coli/genetics; Escherichia coli/radiation effects; Escherichia coli Proteins; Hydroxyl Radical/chemistry; Hydroxyl Radical/radiation effects; Lac Operon/radiation effects; Lac Repressors; Macromolecular Substances; Models, Molecular; Monte Carlo Method; Nucleic Acid Conformation; Operator Regions, Genetic/radiation effects; Protein Conformation; Radiation Tolerance; Repressor Proteins/chemistry; Repressor Proteins/radiation effects
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