PMID:11395429

Citation	Karp, PD, Paley, S and Zhu, J (2001) Database verification studies of SWISS-PROT and GenBank. Bioinformatics 17:526-32; discussion 533-4
Abstract	We have studied the relationships among SWISS-PROT, TrEMBL, and GenBank with two goals. First is to determine whether users can reliably identify those proteins in SWISS-PROT whose functions were determined experimentally, as opposed to proteins whose functions were predicted computationally. If this information was present in reasonable quantities, it would allow researchers to decrease the propagation of incorrect function predictions during sequence annotation, and to assemble training sets for developing the next generation of sequence-analysis algorithms. Second is to assess the consistency between translated GenBank sequences and sequences in SWISS-PROT and TrEMBL.
Links	PubMed
Keywords	Algorithms; Base Sequence; Data Interpretation, Statistical; Databases, Factual/standards; Escherichia coli/classification; Escherichia coli/genetics; Gene Library; Haemophilus influenzae/genetics; Helicobacter pylori/genetics; Human Genome Project; Open Reading Frames/genetics; Protein Biosynthesis/genetics; Species Specificity
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