PMID:11380617
| Citation |
Sen, R, Nagai, H and Shimamoto, N (2001) Conformational switching of Escherichia coli RNA polymerase-promoter binary complex is facilitated by elongation factor GreA and GreB. Genes Cells 6:389-401 |
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| Abstract |
The initiation arrest at a modified lambdaPR promoter is caused by irreversible divergence of the reaction pathway into productive and arrested branches. Escherichia coli GreA and GreB induce cleavage of the nascent transcript and relieve arrest in elongation. They also reduce abortive synthesis at several promoters and relieve initiation arrest. Their mechanism of action during initiation, and its relationship to the branched initiation pathway are unknown. |
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| Keywords |
Base Sequence; Binding Sites; DNA-Directed RNA Polymerases/metabolism; Electrophoresis, Polyacrylamide Gel; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins; Models, Genetic; Mutation; Promoter Regions, Genetic; Protein Conformation; RNA-Binding Proteins/metabolism; Templates, Genetic; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic; Transcriptional Elongation Factors |
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