PMID:11378375
| Citation |
Reck, F, Marmor, S, Fisher, S and Wuonola, MA (2001) Inhibitors of the bacterial cell wall biosynthesis enzyme MurC. Bioorg. Med. Chem. Lett. 11:1451-4 |
|---|---|
| Abstract |
A series of phosphinate transition-state analogues of the L-alanine adding enzyme (MurC) of bacterial peptidoglycan biosynthesis was prepared and tested as inhibitors of the Escherichia coli enzyme. Compound 4 was identified as a potent inhibitor of MurC from Escherichia coli with an IC(50) of 49nM. |
| Links | |
| Keywords |
Cell Wall/drug effects; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Escherichia coli/drug effects; Escherichia coli/enzymology; Peptide Synthases/antagonists & inhibitors; Peptide Synthases/metabolism; Peptidoglycan/metabolism |
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