PMID:11377793
| Citation |
Aguilera, A (2001) Double-strand break repair: are Rad51/RecA--DNA joints barriers to DNA replication? Trends Genet. 17:318-21 |
|---|---|
| Abstract |
The central step of homologous recombination is the DNA strand exchange reaction catalyzed by bacterial RecA or eukaryotic Rad51. Besides Rad51-mediated synthesis-dependent strand annealing (SDSA), DNA ends can promote replication in Escherichia coli (recombination-dependent replication, RDR) and yeast (break-induced replication, BIR). However, what causes a DNA end to be repaired via SDSA or via BIR/RDR? I propose that Rad51/RecA--DNA plectonemic joints act as barriers to DNA replication and that BIR/RDR is only possible when the DNA polymerase that synthesizes DNA from the invading 3' end does not encounter RecA/Rad51--DNA joints in its path. |
| Links | |
| Keywords |
Animals; DNA/chemistry; DNA/genetics; DNA Damage; DNA Nucleotidyltransferases/metabolism; DNA Repair; DNA Replication; DNA-Binding Proteins/metabolism; Escherichia coli/genetics; Rad51 Recombinase; Rec A Recombinases/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins |
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