PMID:11377200
| Citation |
Liao, DI, Wawrzak, Z, Calabrese, JC, Viitanen, PV and Jordan, DB (2001) Crystal structure of riboflavin synthase. Structure 9:399-408 |
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| Abstract |
Riboflavin synthase catalyzes the dismutation of two molecules of 6,7-dimethyl-8-(1'-D-ribityl)-lumazine to yield riboflavin and 4-ribitylamino-5-amino-2,6-dihydroxypyrimidine. The homotrimer of 23 kDa subunits has no cofactor requirements for catalysis. The enzyme is nonexistent in humans and is an attractive target for antimicrobial agents of organisms whose pathogenicity depends on their ability to biosynthesize riboflavin. |
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| Keywords |
Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Escherichia coli/enzymology; Models, Molecular; Molecular Sequence Data; Protein Structure, Quaternary; Pteridines/chemistry; Riboflavin Synthase/chemistry; Riboflavin Synthase/genetics; Substrate Specificity |
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