PMID:11341995
| Citation |
Walker, GC (2001) Bryn Bridges and mutagenesis: exploring the intellectual space. Mutat. Res. 485:69-81 |
|---|---|
| Abstract |
The products of the SOS-regulated umuDC genes are required for most UV and chemical mutagenesis in Escherichia coli. Recently it has been recognized that UmuC is the founding member of a superfamily of novel DNA polymerases found in all three kingdoms of life. Key findings leading to these insights are reviewed, placing a particular emphasis on contributions made by Bryn Bridges and on his interest in the importance of interactions between the umuDC gene products and the replicative DNA polymerase. |
| Links | |
| Keywords |
Bacterial Proteins/genetics; DNA Damage; DNA-Directed DNA Polymerase; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli/radiation effects; Escherichia coli Proteins; Genes, Bacterial; History, 20th Century; Models, Genetic; Mutagenesis; SOS Response (Genetics)/genetics; Ultraviolet Rays/adverse effects |
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