PMID:11321576

Citation	Nikaido, H and Zgurskaya, HI (2001) AcrAB and related multidrug efflux pumps of Escherichia coli. J. Mol. Microbiol. Biotechnol. 3:215-8
Abstract	The AcrAB system of Escherichia coli is a multidrug efflux system composed of an RND-type transporter AcrB and a periplasmic accessory protein AcrA, and pumps out a wide variety of lipophilic and amphiphilic inhibitors directly into the medium, presumably through the TolC outer membrane channel. AcrA, a highly elongated protein, is thought to bring the outer and inner membranes closer. It forms a trimer that interacts with a monomeric AcrB, which was shown by in vitro reconstitution to be a proton antiporter. Details of interaction between the
Links	PubMed
Keywords	Bacterial Outer Membrane Proteins/chemistry; Bacterial Outer Membrane Proteins/metabolism; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Binding Sites; Carrier Proteins/metabolism; Drug Resistance, Microbial; Drug Resistance, Multiple; Escherichia coli/genetics; Escherichia coli/physiology; Escherichia coli Proteins; Lipoproteins/chemistry; Lipoproteins/metabolism; Membrane Proteins/chemistry; Membrane Proteins/metabolism; Membrane Transport Proteins; Models, Molecular; Multidrug Resistance-Associated Proteins; Protein Structure, Secondary
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