PMID:11286891
| Citation |
Franco, MG, Laber, B, Huber, R and Clausen, T (2001) Structural basis for the function of pyridoxine 5'-phosphate synthase. Structure 9:245-53 |
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| Abstract |
Pyridoxal 5'-phosphate is the active form of vitamin B(6) that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In Escherichia coli, the pathway of the de novo biosynthesis of vitamin B(6) results in the formation of pyridoxine 5'-phosphate (PNP), which can be regarded as the first synthesized B(6) vitamer. PNP synthase (commonly referred to as PdxJ) is a homooctameric enzyme that catalyzes the final step in this pathway, a complex intramolecular condensation reaction between 1-deoxy-D-xylulose-5'-phosphate and 1-amino-acetone-3-phosphate. |
| Links | |
| Keywords |
Bacterial Proteins/chemistry; Binding Sites; Crystallography, X-Ray; Escherichia coli/chemistry; Escherichia coli Proteins; Ligases; Models, Molecular; Protein Binding; Protein Structure, Quaternary; Pyridoxal Phosphate/analogs & derivatives; Pyridoxal Phosphate/chemistry; Pyridoxine/biosynthesis |
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