PMID:11286890
| Citation |
Olsen, JG, Kadziola, A, von Wettstein-Knowles, P, Siggaard-Andersen, M and Larsen, S (2001) Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery. Structure 9:233-43 |
|---|---|
| Abstract |
beta-ketoacyl-acyl carrier protein synthase (KAS) I is vital for the construction of the unsaturated fatty acid carbon skeletons characterizing E. coli membrane lipids. The new carbon-carbon bonds are created by KAS I in a Claisen condensation performed in a three-step enzymatic reaction. KAS I belongs to the thiolase fold enzymes, of which structures are known for five other enzymes. |
| Links | |
| Keywords |
3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/chemistry; Catalysis; Catalytic Domain; Crystallography, X-Ray; Decarboxylation; Escherichia coli/chemistry; Fatty Acid Synthetase Complex/chemistry; Fatty Acids/chemistry; Isoenzymes/chemistry; Models, Molecular |
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