PMID:11282473

Citation	Hantke, K (2001) Iron and metal regulation in bacteria. Curr. Opin. Microbiol. 4:172-7
Abstract	In Escherichia coli, the iron regulator Fur is regulated by two oxidative-stress response regulators. The generation of dangerous radicals by oxygen and iron is the basis for this dual regulation, which is also found in eukaryotes. The binding of iron-regulated transcripts to apo-aconitase and results of mRNA half-life studies indicate that there is post-transcriptional iron regulation in bacteria, as in eukaryotes. Fur contains two metal-binding sites, one for Zn2+ and one for Fe2+. Zinc uptake systems are regulated by members of the Fur protein family, and zinc is a cofactor. DtxR and related proteins constitute another family of iron regulators, first found in Gram-positive organisms with a high GC content. In organisms with Fur-dependent iron regulation, members of the DtxR family regulate manganese transport.
Links	PubMed
Keywords	Aconitate Hydratase/genetics; Aconitate Hydratase/metabolism; Bacteria/genetics; Bacteria/metabolism; Bacterial Proteins/metabolism; DNA-Binding Proteins/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression Regulation, Bacterial; Iron/metabolism; Manganese/metabolism; RNA Processing, Post-Transcriptional; Repressor Proteins/metabolism; Siderophores/genetics; Siderophores/metabolism; Transcription, Genetic; Zinc/metabolism
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