PMID:11269495

Citation	Andersen, C, Hughes, C and Koronakis, V (2000) Chunnel vision. Export and efflux through bacterial channel-tunnels. EMBO Rep. 1:313-8
Abstract	The Escherichia coli TolC protein is central to toxin export and drug efflux across the inner and outer cell membranes and the intervening periplasmic space. The crystal structure has revealed that TolC assembles into a remarkable alpha-helical trans-periplasmic cylinder (tunnel) embedded in the outer membrane by a contiguous beta-barrel (channel), so providing a large duct open to the outside environment. The channel-tunnel structure is conserved in TolC homologues throughout Gram-negative bacteria, and it is envisaged that they are recruited and opened, through a common mechanism, by substrate-specific inner-membrane complexes.
Links	PubMed PMC1083749 Online version:10.1093/embo-reports/kvd075
Keywords	Bacterial Outer Membrane Proteins/chemistry; Bacterial Outer Membrane Proteins/metabolism; Biological Transport; Crystallography, X-Ray; Escherichia coli/metabolism; Escherichia coli Proteins; Ion Channels/metabolism; Membrane Transport Proteins; Models, Molecular; Phylogeny; Protein Conformation; Protein Structure, Tertiary
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