PMID:11179887
| Citation |
Bell, CE and Lewis, M (2001) The Lac repressor: a second generation of structural and functional studies. Curr. Opin. Struct. Biol. 11:19-25 |
|---|---|
| Abstract |
In the past year, the crystal structure of a dimeric version of the Escherichia coli Lac repressor bound to operator DNA was determined at 2.6A resolution, providing a closer view of the operator-bound conformation of the repressor. Refined NMR studies of the DNA-binding portion of the repressor complexed to operator DNA have revealed further details of the unique DNA-binding interactions of the repressor. The structural studies have been complemented by continued biochemical studies, with the overall goal of understanding the mechanism of allosteric regulation. |
| Links | |
| Keywords |
Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Escherichia coli Proteins; Lac Repressors; Models, Molecular; Operator Regions, Genetic; Protein Binding; Protein Conformation; Repressor Proteins/chemistry; Repressor Proteins/metabolism; Surface Properties |
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