PMID:11179804
| Citation |
Pomposiello, PJ and Demple, B (2001) Redox-operated genetic switches: the SoxR and OxyR transcription factors. Trends Biotechnol. 19:109-14 |
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| Abstract |
Two redox-responsive transcription regulators have been well defined in Escherichia coli and serve as paradigms of redox-operated genetic switches. SoxR contains iron-sulfur centers that activate the protein when they are one-electron oxidized, or nitrosylated by nitric oxide. OxyR contains a pair of redox-active cysteine residues that activate the protein when they are oxidized to form a disulfide bond. |
| Links | |
| Keywords |
Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Biotechnology; DNA-Binding Proteins; Disulfides/chemistry; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; Free Radicals/metabolism; Hydrogen Peroxide/metabolism; Nitric Oxide/metabolism; Oxidation-Reduction; Repressor Proteins/chemistry; Repressor Proteins/genetics; Repressor Proteins/metabolism; Superoxides/metabolism; Transcription Factors/chemistry; Transcription Factors/genetics; Transcription Factors/metabolism; Transcriptional Activation |
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