PMID:11179648
| Citation |
Jiménez-Arribas, G, Léautaud, V and Amábile-Cuevas, CF (2001) Regulatory locus soxRS partially protects Escherichia coli against ozone. FEMS Microbiol. Lett. 195:175-7 |
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| Abstract |
Ozone is one of the major city air pollutants. Since it is known to induce the overexpression of superoxide-dismutase in various models, and is also a powerful oxidant, we tested if ozone can induce the expression of the soxRS regulon of Escherichia coli, which is activated by superoxide and nitric oxide. A sub-lethal exposure to ozone was unable to activate the expression of soxS'::lacZ transcriptional fusions. However, cells lacking the soxRS locus were more susceptible than wild-type to ozone-mediated killing. Constitutive expression of the soxRS regulon did not increase the resistance to ozone. Ozone might be exerting a selective pressure upon oxidative-stress defense mechanisms in airborne bacteria. |
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| Keywords |
Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Enzyme Induction; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Isopropyl Thiogalactoside/pharmacology; Ozone/pharmacology; Plasmids; Recombinant Fusion Proteins/metabolism; Regulon; Superoxide Dismutase/biosynthesis; Trans-Activators; Transcription Factors/genetics; Transcription Factors/metabolism |
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