PMID:11178260
| Citation |
Gerlt, JA and Babbitt, PC (2000) Can sequence determine function? Genome Biol. 1:REVIEWS0005 |
|---|---|
| Abstract |
The functional annotation of proteins identified in genome sequencing projects is based on similarities to homologs in the databases. As a result of the possible strategies for divergent evolution, homologous enzymes frequently do not catalyze the same reaction, and we conclude that assignment of function from sequence information alone should be viewed with some skepticism. |
| Links |
PubMed PMC138884 Online version:10.1186/gb-2000-1-5-reviews0005 |
| Keywords |
Animals; Binding Sites/genetics; DNA/chemistry; DNA/genetics; Enzymes/genetics; Enzymes/metabolism; Genome; Humans; Sequence Alignment; Sequence Analysis, DNA; Substrate Specificity |
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