PMID:11165499
| Citation |
Buchanan, SK (2001) Type I secretion and multidrug efflux: transport through the TolC channel-tunnel. Trends Biochem. Sci. 26:3-6 |
|---|---|
| Abstract |
The crystal structure of TolC from Escherichia coli was recently determined to 2.1-A resolution and shows a unique type of channel architecture: a 12-stranded beta-barrel spans the outer membrane and is attached to a long alpha-helical channel that penetrates far into the periplasm. The structure suggests a mechanism for its role in secretion of proteins and in efflux of toxic small molecules. The TolC export pathway is compared with several import pathways of gram-negative bacteria where the outer membrane protein structures are also known. |
| Links | |
| Keywords |
Bacterial Outer Membrane Proteins/chemistry; Bacterial Outer Membrane Proteins/metabolism; Bacterial Outer Membrane Proteins/secretion; Biological Transport; Cell Membrane/metabolism; Escherichia coli/metabolism; Escherichia coli Proteins; Gram-Negative Bacteria/metabolism; Membrane Transport Proteins; Pharmaceutical Preparations/metabolism; Protein Conformation |
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