PMID:11160115

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Citation

Zhao, J, Leung, HE and Winkler, ME (2001) The miaA mutator phenotype of Escherichia coli K-12 requires recombination functions. J. Bacteriol. 183:1796-800

Abstract

miaA mutants, which contain A-37 instead of the ms(2)i(6)A-37 hypermodification in their tRNA, show a moderate mutator phenotype leading to increased GC-->TA transversion. We show that the miaA mutator phenotype is dependent on recombination functions similar to, but not exactly the same as, those required for translation stress-induced mutagenesis.

Links

PubMed PMC95069 Online version:10.1128/JB.183.5.1796-1800.2001

Keywords

Adenosine Triphosphatases; Alkyl and Aryl Transferases/genetics; Alkyl and Aryl Transferases/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Base Pair Mismatch; DNA Repair; DNA-Binding Proteins; Escherichia coli/classification; Escherichia coli/genetics; Escherichia coli Proteins; MutS DNA Mismatch-Binding Protein; Mutation; Phenotype; RNA, Transfer, His/genetics; RNA, Transfer, His/metabolism; Recombination, Genetic; Sulfurtransferases/genetics; Sulfurtransferases/metabolism

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