PMID:11084351

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Citation

Jiricny, J (2000) Mismatch repair: the praying hands of fidelity. Curr. Biol. 10:R788-90

Abstract

High-resolution crystal structures have recently been solved for the mismatch binding protein MutS of Escherichia coli and its Thermus aquaticus homologue; they show how these factors recognise such structurally diverse substrates as base-base mismatches and insertion/deletion loops.

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Keywords

Adenosine Triphosphatases; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Base Pair Mismatch; DNA Repair; DNA-Binding Proteins; Escherichia coli/chemistry; Escherichia coli/metabolism; Escherichia coli Proteins; Macromolecular Substances; Models, Molecular; MutS DNA Mismatch-Binding Protein; Protein Structure, Quaternary; Thermus/chemistry; Thermus/metabolism

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