PMID:11056533

Citation	Shimizu, TS, Le Novère, N, Levin, MD, Beavil, AJ, Sutton, BJ and Bray, D (2000) Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis. Nat. Cell Biol. 2:792-6
Abstract	Coliform bacteria detect chemical attractants by means of a membrane-associated cluster of receptors and signalling molecules. We have used recently determined molecular structures, in conjunction with plastic models generated by three-dimensional printer technology, to predict how the proteins of the complex are arranged in relation to the plasma membrane. The proposed structure is a regular two-dimensional lattice in which the cytoplasmic ends of chemotactic-receptor dimers are inserted into a hexagonal array of CheA and CheW molecules. This structure creates separate compartments for adaptation and downstream signalling, and indicates a possible basis for the spread of activity within the cluster.
Links	PubMed Online version:10.1038/35041030
Keywords	Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Chemotaxis/physiology; Escherichia coli/physiology; Escherichia coli Proteins; Membrane Proteins/chemistry; Membrane Proteins/metabolism; Models, Molecular; Protein Structure, Quaternary; Receptors, Cell Surface/chemistry; Receptors, Cell Surface/metabolism; Signal Transduction; Structure-Activity Relationship; Thermotoga maritima/chemistry
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