PMID:11017076

Citation	Tillier, ER and Collins, RA (2000) Genome rearrangement by replication-directed translocation. Nat. Genet. 26:195-7
Abstract	Gene order in bacteria is poorly conserved during evolution. For example, although many homologous genes are shared by the proteobacteria Escherichia coli, Haemophilus influenzae and Helicobacter pylori, their relative positions are very different in each genome, except local functional clusters such as operons. The complete sequences of the more closely related bacterial genomes, such as pairs of Chlamydia, H. pylori and Mycobacterium species, now allow identification of the processes and mechanisms involved in genome evolution. Here we provide evidence that a substantial proportion of rearrangements in gene order results from recombination sites that are determined by the positions of the replication forks. Our observations suggest that replication has a major role in directing genome evolution.
Links	PubMed Online version:10.1038/79918
Keywords	Biological Evolution; Chlamydia/genetics; DNA Replication; Escherichia coli/genetics; Gene Rearrangement; Genome, Bacterial; Haemophilus influenzae/genetics; Helicobacter pylori/genetics; Models, Genetic; Proteobacteria/genetics; Recombination, Genetic; Translocation, Genetic
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