PMID:11001586
| Citation |
Edwards, JS and Palsson, BO (2000) Metabolic flux balance analysis and the in silico analysis of Escherichia coli K-12 gene deletions. BMC Bioinformatics 1:1 |
|---|---|
| Abstract |
Genome sequencing and bioinformatics are producing detailed lists of the molecular components contained in many prokaryotic organisms. From this 'parts catalogue' of a microbial cell, in silico representations of integrated metabolic functions can be constructed and analyzed using flux balance analysis (FBA). FBA is particularly well-suited to study metabolic networks based on genomic, biochemical, and strain specific information. |
| Links |
PubMed PMC29061 Online version:10.1186/1471-2105-1-1 |
| Keywords |
Computational Biology/methods; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Deletion; Genes, Bacterial/genetics; Genes, Essential/genetics; Genotype; Models, Biological; Phenotype |
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