PMID:10991887
| Citation |
Xiong, A, Gottman, A, Park, C, Baetens, M, Pandza, S and Matin, A (2000) The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region. Antimicrob. Agents Chemother. 44:2905-7 |
|---|---|
| Abstract |
EmrR negatively regulates the transcription of the multidrug resistance pump-encoding operon, emrRAB, by binding to its regulatory region. The binding site spans the promoter and the downstream sequence up to the transcriptional start site of the operon. Structurally unrelated drugs that induce the pump interfere with this binding. |
| Links | |
| Keywords |
Bacterial Proteins/pharmacology; Down-Regulation/drug effects; Drug Resistance, Multiple; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli Proteins; Gene Expression Regulation, Bacterial/drug effects; Genes, Bacterial/drug effects; Genes, Bacterial/genetics; Operon/genetics; Promoter Regions, Genetic/drug effects; Promoter Regions, Genetic/genetics; Regulatory Sequences, Nucleic Acid/drug effects; Regulatory Sequences, Nucleic Acid/genetics; Repressor Proteins/pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors |
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