PMID:10986266
| Citation |
Sarker, S, Rudd, KE and Oliver, D (2000) Revised translation start site for secM defines an atypical signal peptide that regulates Escherichia coli secA expression. J. Bacteriol. 182:5592-5 |
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| Abstract |
The secretion-responsive regulation of Escherichia coli secA occurs by coupling its translation to the translation and secretion of an upstream regulator, secM (formerly geneX). We revise the translational start site for secM, defining a new signal peptide sequence with an extended amino-terminal region. Mutational studies indicate that certain atypical amino acyl residues within this extended region are critical for proper secA regulation. |
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| Keywords |
Adenosine Triphosphatases/genetics; Amino Acid Sequence; Bacterial Proteins/genetics; Carrier Proteins/genetics; Codon, Initiator; Escherichia coli/genetics; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genes, Bacterial; Membrane Transport Proteins; Molecular Sequence Data; Protein Biosynthesis; Protein Sorting Signals/genetics; Protein Sorting Signals/physiology |
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