PMID:10973052
| Citation |
Kisters-Woike, B, Vangierdegom, C and Müller-Hill, B (2000) On the conservation of protein sequences in evolution. Trends Biochem. Sci. 25:419-21 |
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| Abstract |
The amino acid sequences of enzymes like alcohol dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase are strongly conserved across all phyla. We suggest that the amino acid conservation of such enzymes might be a result of the fact that they function as part of a multi-enzyme complex. The specific interactions between the proteins involved would hinder evolutionary change of their surfaces. |
| Links | |
| Keywords |
Alcohol Dehydrogenase/chemistry; Bacterial Proteins/chemistry; Conserved Sequence; DNA, Complementary/metabolism; Enzymes/genetics; Escherichia coli/enzymology; Escherichia coli Proteins; Evolution, Molecular; Gene Transfer Techniques; Glyceraldehyde-3-Phosphate Dehydrogenases/chemistry; Humans; Lac Repressors; Models, Molecular; Repressor Proteins/chemistry |
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