PMID:10932248

Citation	Raghunathan, S, Kozlov, AG, Lohman, TM and Waksman, G (2000) Structure of the DNA binding domain of E. coli SSB bound to ssDNA. Nat. Struct. Biol. 7:648-52
Abstract	The structure of the homotetrameric DNA binding domain of the single stranded DNA binding protein from Escherichia coli (Eco SSB) bound to two 35-mer single stranded DNAs was determined to a resolution of 2.8 A. This structure describes the vast network of interactions that results in the extensive wrapping of single stranded DNA around the SSB tetramer and suggests a structural basis for its various binding modes.
Links	PubMed Online version:10.1038/77943
Keywords	Binding Sites; Crystallography, X-Ray; DNA, Single-Stranded/chemistry; DNA, Single-Stranded/genetics; DNA, Single-Stranded/metabolism; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/metabolism; Escherichia coli/chemistry; Models, Molecular; Molecular Sequence Data; Oligodeoxyribonucleotides/chemistry; Oligodeoxyribonucleotides/genetics; Oligodeoxyribonucleotides/metabolism; Peptide Fragments/chemistry; Peptide Fragments/metabolism; Protein Binding; Protein Structure, Quaternary; Spectrometry, Fluorescence; Structure-Activity Relationship; Thermodynamics
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