PMID:1093179
| Citation |
Zipkas, D and Riley, M (1975) Proposal concerning mechanism of evolution of the genome of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 72:1354-8 |
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| Abstract |
Many pairs of genes whose gene products are functionally related lie either 90 degrees or 180 degrees apart on the circular map of the E. coli chromosome. A mechanism of evolution is proposed that involves two sequential duplications of an ancestral genome, followed by mutation and divergence of function of replicate genes. |
| Links | |
| Keywords |
Biological Evolution; Chromosome Mapping; Chromosomes, Bacterial/analysis; Chromosomes, Bacterial/metabolism; DNA Replication; DNA, Bacterial/analysis; DNA, Circular/analysis; Escherichia coli/analysis; Escherichia coli/metabolism; Gene Frequency; Genes; Operon |
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