PMID:1091625
| Citation |
Heffron, F, Sublett, R, Hedges, RW, Jacob, A and Falkow, S (1975) Origin of the TEM-beta-lactamase gene found on plasmids. J. Bacteriol. 122:250-6 |
|---|---|
| Abstract |
A sequence of deoxyribonucleic acid of 2.7 times 10-6 to 3.3 times 10-6 daltons which includes the TEM beta-lactamase gene is present on the small plasmid RSF 1030 (R-Amp). This same sequence is present on plasmid derivatives that have received a translocation of deoxyribonucleic acid specifying the TEM beta-lactamase and is also present on naturally occurring plasmids of the F1, F11, N, X, O, I, C, and W incompatibility groups that do not specify ampicillin resistance or specify O-type beta-lactamases. |
| Links | |
| Keywords |
Ampicillin/pharmacology; Base Sequence; Centrifugation, Density Gradient; DNA, Bacterial/analysis; Escherichia coli/drug effects; Escherichia coli/enzymology; Extrachromosomal Inheritance; Genes; Microscopy, Electron; Molecular Weight; Nucleic Acid Hybridization; Penicillin G/pharmacology; Penicillin Resistance; Penicillinase/biosynthesis; Thymine |
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