PMID:10858363
| Citation |
Sabaté, M, Tarragó, R, Navarro, F, Miró, E, Vergés, C, Barbé, J and Prats, G (2000) Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-9) from Escherichia coli in Spain. Antimicrob. Agents Chemother. 44:1970-3 |
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| Abstract |
A new CTX-M-type beta-lactamase (CTX-M-9) has been cloned from a clinical cefotaxime-resistant Escherichia coli strain. Despite the close identity that exists between the CTX-M-9 and Toho-2 beta-lactamases (88%), the 35 amino acids located between residues Ala-185 and Ala-219 are totally different in both enzymes. Outside of this region there are only six amino acids substitutions between both proteins. |
| Links | |
| Keywords |
Amino Acid Sequence; Cefotaxime/metabolism; Cefotaxime/pharmacology; Cephalosporins/metabolism; Cephalosporins/pharmacology; Cloning, Molecular; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins; Hydrolysis; Molecular Sequence Data; Sequence Homology, Amino Acid; Spain; beta-Lactamases/genetics; beta-Lactamases/metabolism |
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