PMID:10843233

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Citation

Ambroise, Y, Mioskowski, C, Leblanc, G and Rousseau, B (2000) Syntheses and properties of photoactivatable sugar derivatives designed to probe the sugar-binding site of melibiose permease. Bioorg. Med. Chem. Lett. 10:1125-7

Abstract

Three new photoreactive sugar analogues bearing an azido, a diazonium salt or a diazirine group as the photophore as well as a tritium atom were developed. Two of these new photoactivatable compounds gave excellent preliminary results, with a high affinity for the melibiose permease of Escherichia coli.

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PubMed

Keywords

Azides/chemical synthesis; Azides/metabolism; Azirines/chemical synthesis; Azirines/metabolism; Binding Sites; Carbohydrate Metabolism; Carbohydrates/chemical synthesis; Carbohydrates/chemistry; Galactosides/chemical synthesis; Galactosides/metabolism; Membrane Transport Proteins/chemistry; Membrane Transport Proteins/metabolism; Nitrophenylgalactosides/chemistry; Photoaffinity Labels/chemical synthesis; Photoaffinity Labels/chemistry; Photoaffinity Labels/metabolism; Symporters

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