PMID:10801458

Citation	Lee, DG and Bell, SP (2000) ATPase switches controlling DNA replication initiation. Curr. Opin. Cell Biol. 12:280-5
Abstract	Proteins that bind and hydrolyze ATP are frequently involved in the early steps of DNA replication. Recent studies of Saccharomyces cerevisiae suggest that two members of the AAA+ ATPase family--the origin recognition complex and Cdc6p--have separable roles for ATP binding and ATP hydrolysis during eukaryotic DNA replication. Intriguingly, the proposed regulation of these eukaryotic replication proteins by ATP has functional similarities to the ATP-dependent control of the DnaA and DnaC initiation factors from Escherichia coli. Comparison of the ATP regulation of these factors suggests that ATP binding and hydrolysis acts as a molecular switch that couples key events during initiation of replication. This switch results in a significant change in protein function.
Links	PubMed
Keywords	Adenosine Triphosphatases/metabolism; Adenosine Triphosphate/metabolism; Bacterial Proteins/metabolism; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; DNA Helicases/metabolism; DNA Replication/physiology; DNA-Binding Proteins/metabolism; Escherichia coli/metabolism; Escherichia coli Proteins; Fungal Proteins/genetics; Fungal Proteins/metabolism; Mutation; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins
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