PMID:10786282
| Citation |
Anantharaman, T, Mishra, B and Schwartz, D' (1999) Genomics via optical mapping. III: Contiging genomic DNA. Proc Int Conf Intell Syst Mol Biol ':18-27 |
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| Abstract |
In this paper, we describe our algorithmic approach to constructing an alignment of (contiging) a set of restriction maps created from the images of individual genomic (uncloned) DNA molecules digested by restriction enzymes. Generally, these DNA segments are sized in the range of 1-4 Mb. The goal is to devise contiging algorithms capable of producing high-quality composite maps rapidly and in a scaleable manner. The resulting software is a key component of our physical mapping automation tools and has been used to create complete maps of various microorganisms (E. coli, P. falciparum and D. radiodurans). Experimental results match known sequence data. |
| Links | |
| Keywords |
Algorithms; Bayes Theorem; Contig Mapping/methods; DNA; Genome, Human; Humans; Models, Statistical; Reproducibility of Results; Restriction Mapping/methods; Sensitivity and Specificity; Software |
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