PMID:10769162
| Citation |
Van Voorst, F and De Kruijff, B (2000) Role of lipids in the translocation of proteins across membranes. Biochem. J. 347 Pt 3:601-12 |
|---|---|
| Abstract |
The architecture of cells, with various membrane-bound compartments and with the protein synthesizing machinery confined to one location, dictates that many proteins have to be transported through one or more membranes during their biogenesis. A lot of progress has been made on the identification of protein translocation machineries and their sorting signals in various organelles and organisms. Biochemical characterization has revealed the functions of several individual protein components. Interestingly, lipid components were also found to be essential for the correct functioning of these translocases. This led to the idea that there is a very intimate relationship between the lipid and protein components that enables them to fulfil their intriguing task of transporting large biopolymers through a lipid bilayer without leaking their contents. In this review we focus on the Sec translocases in the endoplasmic reticulum and the bacterial inner membrane. We also highlight the interactions of lipids and proteins during the process of translocation and integrate this into a model that enables us to understand the role of membrane lipid composition in translocase function. |
| Links | |
| Keywords |
Adenosine Triphosphatases/metabolism; Animals; Bacterial Proteins; Biological Transport; Carrier Proteins/metabolism; Cell Membrane/metabolism; Escherichia coli/enzymology; Escherichia coli/metabolism; Escherichia coli Proteins; Eukaryotic Cells/enzymology; Eukaryotic Cells/metabolism; Membrane Lipids/metabolism; Membrane Proteins/metabolism; Membrane Transport Proteins; Phospholipids/metabolism; Protein Sorting Signals/metabolism; Proteins/metabolism; Yeasts/enzymology; Yeasts/metabolism |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.