PMID:10759888
| Citation |
Nanbu-Wakao, R, Asoh, S, Nishimaki, K, Tanaka, R and Ohta, S (2000) Bacterial cell death induced by human pro-apoptotic Bax is blocked by an RNase E mutant that functions in an anti-oxidant pathway. Genes Cells 5:155-67 |
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| Abstract |
Bax is a member of the Bcl-2 family and induces apoptosis of mammalian cells. We have shown that a trace amount of human Bax induces the cell death of Escherichia coli, accompanied by damage to DNA, and that the region of Bax which is lethal to E. coli is also responsible for apoptosis-inducing activity in the mammalian cells. |
| Links | |
| Keywords |
Apoptosis; DNA Damage; Endoribonucleases/genetics; Escherichia coli/genetics; Gene Expression Regulation, Bacterial; Gene Transfer Techniques; Humans; Mutation; Oxidative Stress; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-bcl-2; bcl-2-Associated X Protein |
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