PMID:10754553
| Citation |
Goodman, MF (2000) Coping with replication 'train wrecks' in Escherichia coli using Pol V, Pol II and RecA proteins. Trends Biochem. Sci. 25:189-95 |
|---|---|
| Abstract |
DNA replication machineries tend to stall when confronted with damaged DNA template sites, causing the biochemical equivalent of a major 'train wreck'. A newly discovered bacterial DNA polymerase, Escherichia coli Pol V, acting in conjunction with the RecA protein, can exchange places with the stalled replicative Pol III core and catalyse 'error-prone' translesion synthesis. In contrast to Pol V-catalysed 'brute-force, sloppier copying', another SOS-induced DNA polymerase, Pol II, plays a pivotal role in an 'error-free', replication-restart DNA repair pathway and probably involves RecA-mediated homologous recombination. |
| Links | |
| Keywords |
Catalysis; DNA Polymerase II/metabolism; DNA Replication; DNA-Directed DNA Polymerase/metabolism; Escherichia coli/genetics; Escherichia coli Proteins; Mutagenesis; SOS Response (Genetics) |
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