PMID:10754552
| Citation |
Marians, KJ (2000) PriA-directed replication fork restart in Escherichia coli. Trends Biochem. Sci. 25:185-9 |
|---|---|
| Abstract |
The encounter of a replication fork with either a damaged DNA template, a nick in the template strand or a 'frozen' protein-DNA complex can stall the replisome and cause it to fall apart. Such an event generates a requirement for replication fork restart if the cell is going to survive. Recent evidence shows that replication fork restart is effected by the action of the recombination proteins generating a substrate for PriA-directed replication fork assembly. |
| Links | |
| Keywords |
Chromosomes, Bacterial; DNA Replication/physiology; DNA-Binding Proteins/physiology; Escherichia coli/genetics; Phenotype; Replication Protein A |
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