PMID:10744992
| Citation |
Franch, T and Gerdes, K (2000) U-turns and regulatory RNAs. Curr. Opin. Microbiol. 3:159-64 |
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| Abstract |
Conventional antisense RNAs, such as those controlling plasmid replication and maintenance, inhibit the function of their target RNAs rapidly and efficiently. Novel findings show that a common U-turn loop structure mediates fast RNA pairing in the majority of these RNA controlled systems. Usually, an antisense RNA regulates a single, cognate target RNA only. Recent reports, however, show that antisense RNAs can act as promiscuous regulators that control multiple genes in concert to integrate complex physiological responses in Escherichia coli. |
| Links | |
| Keywords |
Base Pairing/genetics; Base Sequence; Escherichia coli/genetics; Gene Expression Regulation, Bacterial/genetics; Genes, Bacterial/genetics; Genes, Regulator/genetics; Genes, Regulator/physiology; Nucleic Acid Conformation; RNA, Antisense/chemistry; RNA, Antisense/genetics; RNA, Antisense/metabolism; RNA, Bacterial/chemistry; RNA, Bacterial/genetics; RNA, Bacterial/metabolism |
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