PMID:10744991

Citation	Nogueira, T and Springer, M (2000) Post-transcriptional control by global regulators of gene expression in bacteria. Curr. Opin. Microbiol. 3:154-8
Abstract	Several authentic or potential global regulators have recently been shown to act at the post-transcriptional level. This is the case for Hfq (HF-1), which is involved in the regulation of an increasing number of genes in Escherichia coli, and CsrA (RsmA) responsible for controlling the expression of genes for extracellular enzymes and secondary metabolism in Gram-negative bacteria. The cold-shock proteins of the CspA family are able to destabilise mRNA secondary structures at low temperature and, therefore, also seem to act post-transcriptionally. These findings illustrate a more general aspect of post-transcriptional control which, in the past, was generally restricted to regulators acting at a single target. The expression of several global transcriptional regulators, such as the stationary phase and heat-shock sigma factors and H-NS, have also recently been shown to be themselves under post-transcriptional control. These examples underline the importance of this type of control in bacterial gene regulation.
Links	PubMed
Keywords	Bacteria/genetics; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Gene Expression Regulation, Bacterial/genetics; Genes, Bacterial/genetics; Genes, Bacterial/physiology; Genes, Regulator/genetics; Genes, Regulator/physiology; Protein Biosynthesis/genetics; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic/genetics
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

Useful Materials and Methods

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Annotations

<annotationlinks/>

EcoliWiki Links

Add links to pages that link here (e.g. gene, product, method pages)

References

See Help:References for how to manage references in EcoliWiki.