PMID:10672041

Citation	Yamaguchi, H, Hanada, K, Asami, Y, Kato, JI and Ikeda, H (2000) Control of genetic stability in Escherichia coli: the SbcB 3'-5' exonuclease suppresses illegitimate recombination promoted by the RecE 5'-3' exonuclease. Genes Cells 5:101-9
Abstract	The Escherichia coli sbcB gene, which codes for a 3'-5' exonuclease, ExoI, is known to suppress illegitimate recombination. In contrast, the recE gene, which codes for a 5'-3' exonuclease, Exo VIII promotes joining between DNA ends having short stretches of homology. Therefore, it seems likely that the 3'-5' and 5'-3' exonucleases regulate genetic instability that is mediated by illegitimate recombination. However, there has been little evidence to substantiate the involvement of exonuclease activity in the promotion and suppression of illegitimate recombination.
Links	PubMed
Keywords	Base Sequence; Escherichia coli/genetics; Escherichia coli Proteins; Exodeoxyribonucleases/genetics; Exodeoxyribonucleases/metabolism; Gene Expression Regulation, Bacterial; Mutation; Plasmids/genetics; Recombination, Genetic; Sequence Deletion; Suppression, Genetic
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