PMID:10662689
| Citation |
Zdraveski, ZZ, Mello, JA, Marinus, MG and Essigmann, JM (2000) Multiple pathways of recombination define cellular responses to cisplatin. Chem. Biol. 7:39-50 |
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| Abstract |
Cisplatin is a DNA-damaging drug used for treatment of testicular tumors. The toxicity of cisplatin probably results from its ability to form DNA adducts that inhibit polymerases. Blocked replication represents a particular challenge for tumor cells, which are committed to unremitting division. Recombination provides a mechanism by which replication can proceed despite the presence of lesions and therefore could be significant for managing cisplatin toxicity. |
| Links | |
| Keywords |
Antineoplastic Agents/pharmacology; Cell Survival/drug effects; Cisplatin/pharmacology; Cross-Linking Reagents/pharmacology; DNA Damage/drug effects; DNA Repair/drug effects; DNA Repair/genetics; Escherichia coli/drug effects; Escherichia coli/genetics; Genotype; Mutation/physiology; Recombination, Genetic/drug effects; Recombination, Genetic/genetics |
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