PMID:10647005

Citation	Herrmann, BG, Koschorz, B, Wertz, K, McLaughlin, KJ and Kispert, A (1999) A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance. Nature 402:141-6
Abstract	Males heterozygous for the t-haplotype form of mouse chromosome 17 preferentially transmit the t-chromosome to their progeny. Several distorter/sterility loci carried on the t-haplotype together impair flagellar function in all spermatozoa whereas the responder, Tcr, rescues t-sperm but not wild-type sperm. Thus, t-sperm have an advantage over wild-type sperm in fertilizing egg cells. We have isolated Tcr by positional cloning and show that it is a member of a novel protein kinase gene family, designated Smok, which is expressed late during spermiogenesis. Smok kinases are components of a signal cascade which may control sperm motility. Tcr has a reduced kinase activity, which may allow it to counterbalance a signalling impairment caused by the distorter/sterility loci. Tcr transgene constructs cause non-mendelian transmission of chromosomes on which they are carried, which leads to sex-ratio distortion when Tcr cosegregates with the Y chromosome.
Links	PubMed Online version:10.1038/45970
Keywords	Amino Acid Sequence; Animals; Cloning, Molecular; Gene Expression; Haplotypes; Male; Mice; Molecular Sequence Data; Multigene Family; Protein Kinases/genetics; Protein Kinases/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Signal Transduction; Sperm Motility; Sperm Tail; Spermatogenesis/genetics; Spermatozoa/enzymology
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

Useful Materials and Methods

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Annotations

<annotationlinks/>

EcoliWiki Links

Add links to pages that link here (e.g. gene, product, method pages)

References

See Help:References for how to manage references in EcoliWiki.