PMID:10637609
| Citation |
Dutta, R and Inouye, M (2000) GHKL, an emergent ATPase/kinase superfamily. Trends Biochem. Sci. 25:24-8 |
|---|---|
| Abstract |
An interesting recent development is the recognition of a novel ATP-binding superfamily that includes diverse protein families such as DNA topoisomerase II, molecular chaperones Hsp90, DNA-mismatch-repair enzymes MutL and histidine kinases. The most singular unifying feature of this superfamily is the unconventional Bergerat ATP-binding fold. The far-reaching significance of this commonality is still in the process of being explored. |
| Links | |
| Keywords |
Adenosine Triphosphatases; Adenosine Triphosphate/metabolism; Amino Acid Motifs; Amino Acid Sequence; Animals; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Binding Sites; Catalytic Domain; DNA Topoisomerases, Type II/chemistry; DNA Topoisomerases, Type II/metabolism; Escherichia coli Proteins; HSP90 Heat-Shock Proteins/chemistry; HSP90 Heat-Shock Proteins/metabolism; Hydrolysis; Molecular Sequence Data; Protein Folding; Protein Kinases/chemistry; Protein Kinases/metabolism |
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