PMID:10536160
| Citation |
Shomer, B and Yagil, G (1999) Long W tracts are over-represented in the Escherichia coli and Haemophilus influenzae genomes. Nucleic Acids Res. 27:4491-500 |
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| Abstract |
The occurrence of DNA tracts of the three binary base combinations: R.Y, K.M and W;S has been mapped in the complete genomes of Haemophilus influenzae and Escherichia coli. A highly significant over-representation of W tracts is observed in both bacteria. The excess of W tracts is particularly striking in the 10% intercoding regions. Subdivision of intercoding regions into divergent (promoting), convergent (terminating) and sequential subregions shows that the excess of W tracts is most concentrated in the promoter regions. A particularly high excess of W tracts is observed in the first 200 bases 5' upstream of coding start sites. The data suggest that W tracts have a role in promoter function. A function as unwinding centers, analogous to the role of R.Y tracts in eukaryotes, is proposed. R.Y and K.M tracts are only modestly over-represented in the two bacteria. |
| Links | |
| Keywords |
Base Pairing; DNA, Bacterial/analysis; DNA, Bacterial/chemistry; Escherichia coli/genetics; Gene Expression Regulation, Bacterial; Haemophilus influenzae/genetics; Promoter Regions, Genetic/physiology; Reading Frames/genetics; Software |
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