PMID:10518736

Citation	Kawamura-Sato, K, Shibayama, K, Horii, T, Iimuma, Y, Arakawa, Y and Ohta, M (1999) Role of multiple efflux pumps in Escherichia coli in indole expulsion. FEMS Microbiol. Lett. 179:345-52
Abstract	Escherichia coli chromosome encodes several multidrug transporters. Despite their protective function against antibacterial agents, the specific physiological actions of these transporters are not fully understood. E. coli produces indole, a metabolite of tryptophan, under physiological conditions. Defined inactivation of the acrEF gene, the product of which is known as an energy-dependent multiple drug efflux pump, decreased indole excretion while reintroduction of the acrEF gene restored it. A DeltaacrEF mutant accumulated more intracellular indole than the parent. This mutant was more susceptible to the growth-inhibitory effect of indole than the parent. These results indicate that the AcrEF system plays a significant role in indole efflux.
Links	PubMed
Keywords	Carrier Proteins/genetics; Carrier Proteins/physiology; Escherichia coli/drug effects; Escherichia coli/metabolism; Indoles/metabolism; Microbial Sensitivity Tests
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