PMID:10515954
| Citation |
Barr, K, Klena, J and Rick, PD (1999) The modality of enterobacterial common antigen polysaccharide chain lengths is regulated by o349 of the wec gene cluster of Escherichia coli K-12. J. Bacteriol. 181:6564-8 |
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| Abstract |
The assembly of the phosphoglyceride-linked form of enterobacterial common antigen (ECA(PG)) occurs by a mechanism that involves modulation of polysaccharide chain length. However, the genetic determinant of this modulation has not been identified. Site-directed mutagenesis of o349 of the Escherichia coli K-12 wec gene cluster revealed that this locus encodes a Wzz protein that specifically modulates the chain length of ECA(PG) polysaccharides, and we have designated this locus wzz(ECA). The Wzz(ECA)-mediated modulation of ECA(PG) polysaccharide chains is the first demonstrated example of Wzz regulation involving a polysaccharide that is not linked to the core-lipid A structure of lipopolysaccharide. |
| Links | |
| Keywords |
Antigens, Bacterial/biosynthesis; Enterobacteriaceae/immunology; Escherichia coli/genetics; Genes, Bacterial; Glycolipids/biosynthesis; Glycolipids/immunology; Multigene Family; Polysaccharides, Bacterial/biosynthesis; Polysaccharides, Bacterial/immunology; Restriction Mapping |
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