PMID:10500101

Citation	Ades, SE, Connolly, LE, Alba, BM and Gross, CA (1999) The Escherichia coli sigma(E)-dependent extracytoplasmic stress response is controlled by the regulated proteolysis of an anti-sigma factor. Genes Dev. 13:2449-61
Abstract	The activity of the stress-responsive sigma factor, sigma(E), is induced by the extracytoplasmic accumulation of misfolded or unfolded protein. The inner membrane protein RseA is the central regulatory molecule in this signal transduction cascade and acts as a sigma(E)-specific anti-sigma factor. Here we show that sigma(E) activity is primarily determined by the ratio of RseA to sigma(E). RseA is rapidly degraded in response to extracytoplasmic stress, leading to an increase in the free pool of sigma(E) and initiation of the stress response. We present evidence that the putative inner membrane serine protease, DegS, is responsible for this regulated degradation of RseA.
Links	PubMed PMC317020
Keywords	Bacterial Proteins/metabolism; Bacterial Proteins/physiology; Cytoplasm/metabolism; Escherichia coli/metabolism; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Reporter; Membrane Proteins/biosynthesis; Membrane Proteins/metabolism; Mutagenesis; Plasmids/metabolism; Precipitin Tests; Sigma Factor/biosynthesis; Sigma Factor/physiology; Signal Transduction; Temperature; Time Factors; Transcription Factors/biosynthesis; Transcription Factors/physiology
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