PMID:10482531
| Citation |
Etchegaray, JP and Inouye, M (1999) A sequence downstream of the initiation codon is essential for cold shock induction of cspB of Escherichia coli. J. Bacteriol. 181:5852-4 |
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| Abstract |
Cold shock induction of cspB has been shown to be primarily regulated at the mRNA level. Here, we demonstrate that the induction of cspB at low temperature also requires the translational cis-acting element called the downstream box (DB). Full induction of cspB at low temperature is achieved in the presence of both the Shine-Dalgarno sequence and DB. We propose that the DB sequence functions as a translational enhancer for the biosynthesis of CspB to bypass the inhibitory effect in translation caused by cold shock. |
| Links | |
| Keywords |
Bacterial Proteins/genetics; Base Pair Mismatch; Base Sequence; Carrier Proteins/genetics; Codon, Initiator/genetics; Cold Temperature; Enhancer Elements, Genetic; Escherichia coli/genetics; Escherichia coli Proteins; Gene Expression Regulation, Bacterial/physiology; Heat-Shock Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Biosynthesis; RNA, Messenger/genetics; RNA, Ribosomal, 16S/genetics; Recombinant Fusion Proteins/biosynthesis; Sequence Alignment; Transcription, Genetic |
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