PMID:10468575

Citation	Thomas, DR, Morgan, DG and DeRosier, DJ (1999) Rotational symmetry of the C ring and a mechanism for the flagellar rotary motor. Proc. Natl. Acad. Sci. U.S.A. 96:10134-9
Abstract	FliG, FliM, and FliN, key proteins for torque generation, are located in two rings. The first protein is in the M ring and the last two are in the C ring. The rotational symmetries of the C and M rings have been determined to be about 34 (this paper) and 26 (previous work), respectively. The mechanism proposed here depends on the symmetry mismatch between the rings: the C ring extends 34 levers, of which 26 can bind to the 26 equivalent sites on the M ring. The remaining 8 levers bind to proton-pore complexes (studs) to form 8 torque generators. Movement results from the swapping of stud-bound levers with M ring-bound levers. The model predicts that both the M and C rings rotate in the same direction but at different speeds.
Links	PubMed PMC17855
Keywords	Bacterial Proteins/chemistry; Bacterial Proteins/physiology; Bacterial Proteins/ultrastructure; Flagella/physiology; Flagella/ultrastructure; Microscopy, Electron; Models, Molecular; Models, Structural; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/ultrastructure; Rotation; Torque
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