PMID:10419969
| Citation |
Alekshun, MN and Levy, SB (1999) Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro. J. Bacteriol. 181:4669-72 |
|---|---|
| Abstract |
MarR negatively regulates expression of the multiple antibiotic resistance operon (marRAB) in Escherichia coli. In this study, it was demonstrated that sodium salicylate, plumbagin, 2, 4-dinitrophenol, and menadione-inducers of the marRAB operon in whole cells-all interfered with the repressor activity of MarR in vitro. It is proposed that these compounds can interact directly with MarR to affect its repressor activity. |
| Links | |
| Keywords |
2,4-Dinitrophenol/pharmacology; Antineoplastic Agents, Phytogenic/pharmacology; Bacterial Proteins/metabolism; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; Naphthoquinones/pharmacology; Operon/drug effects; Plasmids; Repressor Proteins/metabolism; Restriction Mapping; Sodium Salicylate/pharmacology; Vitamin K/pharmacology |
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